Santa Clara, CA August 25, 2008 Symyx Technologies, Inc. (Nasdaq: SMMX) today announced plans to provide a live webcast of its presentation at the Thomas Weisel Healthcare Conference. The presentation, which is scheduled to begin at 8:00 a.m. ET on Thursday, September 4th, will include an overview of the company, its business units and products, and other matters relating to its business. The webcast audio and slides will be available in the Investors section of the company’s web site at www.symyx.com for a period of two weeks.

Symyx Technologies, Inc. is the scientific R&D integration partner to companies in the life sciences, chemicals, energy, electronics and consumer products industries. With scientific R&D under tremendous economic and technical pressure, we help companies reduce R&D risk and enhance R&D productivity to help them bring more and better products to market quickly and cost-effectively. Our integrated technology platform combines electronic laboratory notebooks, content, laboratory logistics and analysis available from Symyx Software, software-driven integrated workflows available from Symyx Tools and collaborative research and directed services from Symyx Research to support the entire R&D process. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.