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Drug Discovery Technology Europe 2001

2001 MDL User Conference

Drug Discovery Technology 2001


Free Combi-Chem Seminar

A Fully Integrated Software and Hardware Solution for Combinatorial Chemistry

MDL and IRORI are teaming up to show you our latest solutions for combinatorial chemistry. There will be two identical Combi-Chem Seminars held at each site. Please feel free to attend which seminar best fits your schedule.

April 23, 2001
Session 1: 9:30 AM to 12:00 PM
Session 2: 1:30 PM to 4:00 PM
Embassy Suites SFO Airport
250 Gateway Boulevard
South San Francisco, CA 94080

April 24, 2001
Session 1: 9:30 AM to 12:00 PM
Session 2: 1:30 PM to 4:00 PM
San Leandro Marina Inn
68 San Leandro Marina
San Leandro, CA 94577



During this free seminar we will demonstrate:
  • The selection of reagents from over 540 commercial chemical suppliers
  • The creation of a combinatorial library and management of combinatorial libraries
  • The Directed Sorting approach to combinatorial chemistry that delivers all the benefits of both parallel synthesis and split-and-pool synthesis
The advantages of using IRORIís Directed Sorting approach include:
  • The production of discrete compounds
  • Multi-milligram quantities of compounds
  • The reaction productivity of split-and-pool
Combinatorial chemistry enables you to generate large quantities of compounds in a very short amount of time. The result is a data management nightmare. Fortunately, MDL offers solutions to aid in the selection of reagents and the management of combinatorial library data.

We will be demonstrating two pieces of the total solution: Reagent Selector and Afferent Teamworks 3.0. We will also be demonstrating the seamless integration of this application suite with the IRORI hardware and software.

The Afferent product suite is a single, integrated software system that spans the modern discovery
chemistry workflow. The 3.0 release of the suite introduces an object-oriented chemical knowledge base that offers planning, archiving, and analysis tools suitable for both combinatorial and classical organic synthesis.

The product suite comprises three functional modules:
  • Afferent Structure, the core of the Afferent suite, enumerates combinatorial product structures using a reaction-based approach to library representation. The system tracks physical locations, ID numbers, and other pertinent product data.
  • Afferent Synthesis, an optional module, enables seamless transfer of reagent and workflow information between Afferent and leading automated systems.
  • Afferent Analytical, an optional module, handles MS and LC/MS data from the most popular instruments used for combinatorial analysis, interpreting the data in the context of product and by-product structures.
Please contact Adrian Popowycz of IRORI or Scott Lyon of MDL to confirm your attendance:
Adrian Popowycz (310) 316-7589
Scott Lyon (510) 357-2222 x1832

We hope to see you there!

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